Endocrine Abstracts

A 30 year old gentleman was admitted to our department with symptoms of tiredness and weight loss over the past 3 weeks. He also gave a history of erectile dysfunction for several years. His only significant past history was asthma well controlled on inhalers. On examination he appeared tanned. There was no buccal or skin crease pigmentation. Smell sensation was normal and he had normal external genitalia and secondary sexual characteristics.Initial inve...

A 74-year-old gardener developed progressive dysphagia for solids and liquids over 15 months. He lost five stone in weight and became increasingly weak. There was nothing significant in his past medical and drug histories. He is married, never smoked and drank little alcohol.He had an acute medical admission via A&E in April 2008 for profound dehydration and cachexia. His weight was 41.5 kg. There were no gross neurological deficits but he had hoarse...

37 year old gentleman presented with Cushing’s disease at the age of 15 with obesity, growth retardation, and vertebral fracture. After bilateral adrenalectomy and pituitary irradiation he was treated with hydrocortisone and fludrocortisone. After being lost to follow up for a number of years he was referred to our endocrine clinic in 1999. Clinical examination revealed that he was obese (BMI 39.2), hypertensive and had marked abdominal striae. Investigations revealed an ...

Section 1: Case history: We present the case of a 35-year-old gentleman referred by his GP to Endocrinology clinic for loss of libido and testosterone deficiency. His co-morbidities included obesity (BMI 59 kg/m2), hypertension and obstructive sleep apnoea (OSA) requiring overnight continuous positive airways pressure (CPAP) therapy. Routine pituitary profile showed luteinising hormone 4.8 IU/l (1–8), testosterone 7.1 nmol/l (8–25), prolactin 232 mU/l (86&...

A 34-year old lady presented in the postpartum period following her 3rd pregnancy with severe hypertension. Her first two pregnancies were 3 and 5 years previously where she delivered via elective Caesarean section without any complications. During this pregnancy which was a twin pregnancy, her antenatal care was mainly unremarkable but on specific questioning, she reported increased sweating for a period of 4 months. Her blood pressure was noted to be normal during her antena...

Introduction: Hormone-secreting teratomas are well described. However teratomas secreting pancreatic hormones are rare, with even fewer cases producing clinically significant effects. We describe possibly the first documented case of hyperinsulinaemic hypoglycaemia due to an insulin-secreting ovarian teratoma.Case report: A 23-year-old woman presented with transient symptoms of lethargy and weakness. She had used her father’s capillary glucose meter...

Case history: We present the case of a 40-year-old man who was referred to a cardiologist with hypertension. He was initiated on bisoprolol and doxazosin. Investigations revealed elevated urinary metanephrines and catecholamines, with normetadrenaline 7.4 μmol/24 h (normal <2), noradrenaline 820 nmol/24 h (normal <500) but normal dopamine levels. He was referred to our clinic. Two further 24 h urine catecholamine assays were elevated. Dexamethasone suppression tes...

Introduction: Palpable thyroid nodules have a prevalence of 4–7%, which increases with imaging. About 5% are malignant. Efficient management is essential. USG and FNAC are valuable in assessing and preventing unnecessary thyroidectomies. Objective To compare our practice with local and Royal College of Pathologists guidelines. Methods All thyroid nodule patients seen in clinic between April to September 2010 were included. Data collected included age, gender, TFT, thyroid...

We describe our patient, a 50 year old lady who developed Addisons disease 10 years ago with typical signs and symptoms of weight loss, hyperpigmentation, tiredness and postural hypotension. She is under follow up at our clinic for last 4 years. Her identical twin was diagnosed with Addisons disease and hypothyroidism at age 27 and with Coeliac disease when she was 43. Both of them are positive for anti-adrenal and TPO antibodies.Our patient developed le...

We present the case of a Caucasian girl who in 1991 at the age of 4 started virilising and was diagnosed to have 21-hydroxylase deficiency. She started her periods at 10 and has been under regular follow up. In 2004 she underwent vaginoplasty and clitoral reduction and made good recovery. She has been stable on hydrocortisone 10 mg in the morning, 12.5 mg in the evening and fludrocortisone 50 mcg once daily (Testosterone<0.7 mmol/l (0.5–3.0), 17-hydroxy progesterone=1...